Prefusion RSV F Immunization Elicits Th2-Mediated Lung Pathology in Mice When Formulated With a Th2 (but Not a Th1/Th2-Balanced) Adjuvant Despite Complete Viral Protection

Respiratory syncytial virus (RSV) remains the most common cause of lower respiratory tract infections in children worldwide. Development of a vaccine has been hindered by the risk of developing enhanced respiratory disease (ERD) upon natural exposure to the virus. Generation of higher quality neutra...

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Hlavní autoři:	Katherine M. Eichinger, Jessica L. Kosanovich, Sonal V. Gidwani, Aaron Zomback, Madeline A. Lipp, Timothy N. Perkins, Tim D. Oury, Nikolai Petrovsky, Christopher P. Marshall, Mark A. Yondola, Kerry M. Empey
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2020-07-01
Edice:	Frontiers in Immunology
Témata:	RSV immunization prefusion infection Th1/Th2-immunity adjuvant
On-line přístup:	https://www.frontiersin.org/article/10.3389/fimmu.2020.01673/full
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