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Prefusion RSV F Immunization Elicits Th2-Mediated Lung Pathology in Mice When Formulated With a Th2 (but Not a Th1/Th2-Balanced) Adjuvant Despite Complete Viral Protection

Respiratory syncytial virus (RSV) remains the most common cause of lower respiratory tract infections in children worldwide. Development of a vaccine has been hindered by the risk of developing enhanced respiratory disease (ERD) upon natural exposure to the virus. Generation of higher quality neutra...

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Kaydedildi:
Asıl Yazarlar: Katherine M. Eichinger, Jessica L. Kosanovich, Sonal V. Gidwani, Aaron Zomback, Madeline A. Lipp, Timothy N. Perkins, Tim D. Oury, Nikolai Petrovsky, Christopher P. Marshall, Mark A. Yondola, Kerry M. Empey
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2020-07-01
Seri Bilgileri:Frontiers in Immunology
Konular:
RSV
immunization
prefusion
infection
Th1/Th2-immunity
adjuvant
Online Erişim:https://www.frontiersin.org/article/10.3389/fimmu.2020.01673/full
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