Therapeutic Response of CCKBR-Positive Tumors to Combinatory Treatment with Everolimus and the Radiolabeled Minigastrin Analogue [¹⁷⁷Lu]Lu-PP-F11N

The inhibition of the mammalian target of rapamycin complex 1 (mTORC1) by everolimus (RAD001) was recently shown to enhance the tumor uptake of radiolabeled minigastrin. In this paper, we investigate if this finding can improve the in vivo therapeutic response to [¹⁷⁷Lu]Lu-PP-F11N treatme...

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Detalhes bibliográficos

Principais autores:	Michal Grzmil, Stefan Imobersteg, Alain Blanc, Stephan Frank, Roger Schibli, Martin P. Béhé
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-12-01
coleção:	Pharmaceutics
Assuntos:	cholecystokinin B receptor (CCKBR) CCK2R minigastrin analogue PP-F11N everolimus RAD001 mammalian target of rapamycin complex 1 (mTORC1)
Acesso em linha:	https://www.mdpi.com/1999-4923/13/12/2156
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