Quality control of actinium-225 and 225Ac-radiopharmaceuticals: Francium-221 to be or not to be?

Abstract Background Actinium-225 radiopharmaceuticals have drawn great interest in cancer therapy due to their tumor-specific delivery of cytotoxic alpha-particles. Quality control (QC) is critical for these potent agents and there is currently no consensus for best practice of actinium-225 QC. Dete...

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Autors principals:	Miguel Toro-Gonzalez, Luke Wheeless, Vijai Kumar Reddy Tangadanchu, Cory Hawkins, Shannon Provo, William Smith, Michael Hommen, Dan DeVries, Jim Harvey, Tyler Drum, Diane S. Abou
Format:	Artigo
Idioma:	Inglês
Publicat:	SpringerOpen 2026-01-01
Col·lecció:	EJNMMI Radiopharmacy and Chemistry
Matèries:	Actinium-225 quality control Liquid scintillation High purity germanium Gamma well counting Thin layer chromatography HPLC
Accés en línia:	https://doi.org/10.1186/s41181-025-00419-7
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