Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study

Abstract Background Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely related to aging. DNA methylation-based epigenetic clock is now recognized as highly accurate predictor of the aging process and associated health outcomes....

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Wanqian Pan, Qi Huang, Le Zhou, Jia Lin, Xiaojiao Du, Xiaodong Qian, Tingbo Jiang, Weixiang Chen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-03-01
Schriftenreihe:	Clinical Epigenetics
Schlagworte:	Aortic valve stenosis Bidirectional Mendelian randomization Biological aging Epigenetic clock Genome-wide association study
Online-Zugang:	https://doi.org/10.1186/s13148-024-01647-5
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!