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Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study

Abstract Background Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely related to aging. DNA methylation-based epigenetic clock is now recognized as highly accurate predictor of the aging process and associated health outcomes....

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Principais autores: Wanqian Pan, Qi Huang, Le Zhou, Jia Lin, Xiaojiao Du, Xiaodong Qian, Tingbo Jiang, Weixiang Chen
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-03-01
Serier:Clinical Epigenetics
Fag:
Aortic valve stenosis
Bidirectional Mendelian randomization
Biological aging
Epigenetic clock
Genome-wide association study
Online adgang:https://doi.org/10.1186/s13148-024-01647-5
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