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New benzimidazole-triazole glycoconjugates as anti-cancer agents and EGFR inhibitors

Abstract A new series of glycosyl heterocyclic scaffolds, 5a-10b with N-glycosidic linkage, were synthesized, starting with 2-acetyl-1H-benzimidazole as a precursor of the propargyl-derived substrates (2) and (3), which were then converted to the target 1,2,3-triazole glycosides (8a-10b) bearing unp...

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Autori principali: Aladdin M. Srour, Mohamed N. El-Bayaa, Ahmed Temirak, Asmaa L. Alanzy, Hanem M. Awad, Asmaa Saleh, Mahmoud G. Saleh, Wael A. El-Sayed
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2025-07-01
Serie:Scientific Reports
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Accesso online:https://doi.org/10.1038/s41598-025-96675-3
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