New benzimidazole-triazole glycoconjugates as anti-cancer agents and EGFR inhibitors

Abstract A new series of glycosyl heterocyclic scaffolds, 5a-10b with N-glycosidic linkage, were synthesized, starting with 2-acetyl-1H-benzimidazole as a precursor of the propargyl-derived substrates (2) and (3), which were then converted to the target 1,2,3-triazole glycosides (8a-10b) bearing unp...

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主要な著者:	Aladdin M. Srour, Mohamed N. El-Bayaa, Ahmed Temirak, Asmaa L. Alanzy, Hanem M. Awad, Asmaa Saleh, Mahmoud G. Saleh, Wael A. El-Sayed
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-07-01
シリーズ:	Scientific Reports
主題:	Benzimidazole 1,2,3-Triazole Anti-cancer LDF assay EGFR Cytotoxicity
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-96675-3
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