CCR2/CXCR6 enhances tumor infiltration and antitumor efficacy of MSLN CAR-T cells

Abstract Chimeric antigen receptor T (CAR-T) cell therapy has shown promise in treating solid tumors, but the clinical success is often limited by insufficient tumor infiltration. In this study, we sought to engineered two MSLN-targeted CAR-T cell variants, Intra2 and Intra6, expressing CCR2 and CXC...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Yan Zhang, Lianfeng Zhao, Jiaqi Liu, Xinhao Yang, Tianyu Chen, Zhengliang Chen, Wenying Li, Zhigang Hu, Feiyan Pan, Jiannan Chen, Lingfeng He, Zhigang Guo
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer 2025-11-01
Serier:	Cellular and Molecular Life Sciences
Fag:	MSLN CAR-T cells Tumor immunotherapy Tumor microenvironment Chemokine receptors Tumor infiltration
Online adgang:	https://doi.org/10.1007/s00018-025-05972-7
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!