Asiaticoside enhances the antitumor efficacy of MSLN-targeted CAR-T cells in ovarian cancer

Abstract Background Chimeric antigen receptor (CAR)-T cell therapy faces significant challenges in treating solid tumors, primarily due to the immunosuppressive tumor microenvironment (TME) and rapid T-cell exhaustion mediated by cytokines such as transforming growth factor-β (TGF-β). Developing str...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Wei Jiang, Juanwen Cao, Qi Li, Yuyan Xie, Xiaoying Li, Xifeng Pan, Miaomiao Yu, Dan Zou, Bonan Sun, Wei Yang, Xiaoyi Huang, Yu Tang
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2026-03-01
Sarja:	Journal of Translational Medicine
Aiheet:	CAR-T cells Mesothelin Asiaticoside TGF-β1 Immunosuppressive tumor microenvironment
Linkit:	https://doi.org/10.1186/s12967-026-08053-w
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