CCR2/CXCR6 enhances tumor infiltration and antitumor efficacy of MSLN CAR-T cells

Abstract Chimeric antigen receptor T (CAR-T) cell therapy has shown promise in treating solid tumors, but the clinical success is often limited by insufficient tumor infiltration. In this study, we sought to engineered two MSLN-targeted CAR-T cell variants, Intra2 and Intra6, expressing CCR2 and CXC...

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Библиографические подробности

Главные авторы:	Yan Zhang, Lianfeng Zhao, Jiaqi Liu, Xinhao Yang, Tianyu Chen, Zhengliang Chen, Wenying Li, Zhigang Hu, Feiyan Pan, Jiannan Chen, Lingfeng He, Zhigang Guo
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Springer 2025-11-01
Серии:	Cellular and Molecular Life Sciences
Предметы:	MSLN CAR-T cells Tumor immunotherapy Tumor microenvironment Chemokine receptors Tumor infiltration
Online-ссылка:	https://doi.org/10.1007/s00018-025-05972-7
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