Near Miss or Standard of Care? <i>DPYD</i> Screening for Cancer Patients Receiving Fluorouracil

5-fluorouracil (5-FU) and its pro-drug capecitabine are widely used anticancer agents. Most 5-FU catabolism is dependent on dihydropyrimidine dehydrogenase (DPD) encoded by the <i>DPYD</i> gene, and <i>DPYD</i> variants that reduce DPD function increase 5-FU toxicity. Most DPD deficient patients are...

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Hlavní autoři:	Lauren E. Winquist, Michael Sanatani, Richard B. Kim, Eric Winquist
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-12-01
Edice:	Current Oncology
Témata:	fluoropyrimidines dihydropyrimidine dehydrogenase cancer adverse effects single nucleotide polymorphisms drug therapy
On-line přístup:	https://www.mdpi.com/1718-7729/28/1/12
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