Near Miss or Standard of Care? <i>DPYD</i> Screening for Cancer Patients Receiving Fluorouracil
5-fluorouracil (5-FU) and its pro-drug capecitabine are widely used anticancer agents. Most 5-FU catabolism is dependent on dihydropyrimidine dehydrogenase (DPD) encoded by the <i>DPYD</i> gene, and <i>DPYD</i> variants that reduce DPD function increase 5-FU toxicity. Most DPD deficient patients are...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI AG
2020-12-01
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| Colecção: | Current Oncology |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/1718-7729/28/1/12 |
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