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Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures

Cyclic nucleotide-modulated channels have important roles in visual signal transduction and pacemaking. Binding of cyclic nucleotides (cAMP/cGMP) elicits diverse functional responses in different channels within the family despite their high sequence and structure homology. The molecular mechanisms...

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Príomhchruthaitheoirí: Jan Rheinberger, Xiaolong Gao, Philipp AM Schmidpeter, Crina M Nimigean
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: eLife Sciences Publications Ltd 2018-07-01
Sraith:eLife
Ábhair:
Rochtain ar líne:https://elifesciences.org/articles/39775
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