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Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel

Visualizing conformational changes during ion channel gating is crucial to understand their regulation. Here, Gao et al. capture multiple gating intermediates in a CNG channel as well as subtle, lateral voltage sensor movements necessary for channel opening.

I tiakina i:
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Ngā kaituhi matua: Xiaolong Gao, Philipp A. M. Schmidpeter, Vladimir Berka, Ryan J. Durham, Chen Fan, Vasanthi Jayaraman, Crina M. Nimigean
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2022-11-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-022-34673-z
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