Reduced Expression of Cerebral Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome

Glutamatergic receptor expression is mostly unknown in adults with fragile X syndrome (FXS). Favorable behavioral effects of negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGluR₅) in <i>fmr1</i> knockout (KO) mouse models have not been confirmed in...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	James R. Brašić, Ayon Nandi, David S. Russell, Danna Jennings, Olivier Barret, Anil Mathur, Keith Slifer, Thomas Sedlak, Samuel D. Martin, Zabecca Brinson, Pankhuri Vyas, John P. Seibyl, Elizabeth M. Berry-Kravis, Dean F. Wong, Dejan B. Budimirovic
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-11-01
Schriftenreihe:	Brain Sciences
Schlagworte:	binding potential caudate nucleus <i>FMR1</i> gene Fragile X Mental Retardation Protein (FMRP) genetic mutation magnetic resonance imaging (MRI)
Online-Zugang:	https://www.mdpi.com/2076-3425/10/12/899
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!