Extreme Diversity of IgGs Against Histones, DNA, and Myelin Basic Protein in the Cerebrospinal Fluid and Blood of Patients with Multiple Sclerosis

It was recently shown that IgGs from sera of multiple sclerosis (MS) patients are active in the hydrolysis of DNA and myelin basic protein (MBP). We first analyzed the relative concentration of antibodies against five histones (H1, H2a, H2b, H3, and H4) in the cerebrospinal fluid (CSF) and serum of...

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Autors principals:	Irina A. Kostrikina, Valentina N. Buneva, Enrico Granieri, Georgy A. Nevinsky
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2020-04-01
Col·lecció:	Biomolecules
Matèries:	multiple sclerosis human cerebrospinal fluid catalytic IgGs DNase activity protease activity extreme diversity of IgGs against auto-antigens
Accés en línia:	https://www.mdpi.com/2218-273X/10/4/630
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