Extreme Diversity of IgGs Against Histones, DNA, and Myelin Basic Protein in the Cerebrospinal Fluid and Blood of Patients with Multiple Sclerosis

It was recently shown that IgGs from sera of multiple sclerosis (MS) patients are active in the hydrolysis of DNA and myelin basic protein (MBP). We first analyzed the relative concentration of antibodies against five histones (H1, H2a, H2b, H3, and H4) in the cerebrospinal fluid (CSF) and serum of...

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Hlavní autoři:	Irina A. Kostrikina, Valentina N. Buneva, Enrico Granieri, Georgy A. Nevinsky
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-04-01
Edice:	Biomolecules
Témata:	multiple sclerosis human cerebrospinal fluid catalytic IgGs DNase activity protease activity extreme diversity of IgGs against auto-antigens
On-line přístup:	https://www.mdpi.com/2218-273X/10/4/630
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