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Extreme Diversity of IgGs Against Histones, DNA, and Myelin Basic Protein in the Cerebrospinal Fluid and Blood of Patients with Multiple Sclerosis

It was recently shown that IgGs from sera of multiple sclerosis (MS) patients are active in the hydrolysis of DNA and myelin basic protein (MBP). We first analyzed the relative concentration of antibodies against five histones (H1, H2a, H2b, H3, and H4) in the cerebrospinal fluid (CSF) and serum of...

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Principais autores: Irina A. Kostrikina, Valentina N. Buneva, Enrico Granieri, Georgy A. Nevinsky
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-04-01
Serier:Biomolecules
Fag:
multiple sclerosis
human cerebrospinal fluid
catalytic IgGs
DNase activity
protease activity
extreme diversity of IgGs against auto-antigens
Online adgang:https://www.mdpi.com/2218-273X/10/4/630
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