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RETRACTED ARTICLE: Hurdles to breakthrough in CAR T cell therapy of solid tumors

Abstract Autologous T cells genetically engineered to express chimeric antigen receptor (CAR) have shown promising outcomes and emerged as a new curative option for hematological malignancy, especially malignant neoplasm of B cells. Notably, when T cells are transduced with CAR constructs, composed...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Faroogh Marofi, Harun Achmad, Dmitry Bokov, Walid Kamal Abdelbasset, Zeid Alsadoon, Supat Chupradit, Wanich Suksatan, Siavash Shariatzadeh, Zahra Hasanpoor, Mahboubeh Yazdanifar, Navid Shomali, Farhad Motavalli Khiavi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2022-04-01
Schriftenreihe:Stem Cell Research & Therapy
Schlagworte:
Chimeric antigen receptor
CAR-T cell
Solid tumors
Tumor microenvironment
Online-Zugang:https://doi.org/10.1186/s13287-022-02819-x
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