The <i>Trypanosoma brucei</i>-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells

The extracellular parasite and causative agent of African sleeping sickness <i>Trypanosoma brucei</i> (<i>T. brucei</i>) has evolved a number of strategies to avoid immune detection in the host. One recently described mechanism involves the conversion of host-derived amino acids to aromatic ketoacid...

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Principais autores:	Hannah K. Fitzgerald, Sinead A. O’Rourke, Eva Desmond, Nuno G. B. Neto, Michael G. Monaghan, Miriam Tosetto, Jayne Doherty, Elizabeth J. Ryan, Glen A. Doherty, Derek P. Nolan, Jean M. Fletcher, Aisling Dunne
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2022-01-01
Series:	Antioxidants
Assuntos:	heme oxygenase 1 <i>Trypanosoma brucei</i> inflammatory bowel disease aromatic ketoacids dendritic cells immunomodulation
Acceso en liña:	https://www.mdpi.com/2076-3921/11/1/164
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