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The <i>Trypanosoma brucei</i>-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells

The extracellular parasite and causative agent of African sleeping sickness <i>Trypanosoma brucei</i> (<i>T. brucei</i>) has evolved a number of strategies to avoid immune detection in the host. One recently described mechanism involves the conversion of host-derived amino acids to aromatic ketoacid...

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Main Authors: Hannah K. Fitzgerald, Sinead A. O’Rourke, Eva Desmond, Nuno G. B. Neto, Michael G. Monaghan, Miriam Tosetto, Jayne Doherty, Elizabeth J. Ryan, Glen A. Doherty, Derek P. Nolan, Jean M. Fletcher, Aisling Dunne
Format: Artigo
Language:Inglês
Published: MDPI AG 2022-01-01
Series:Antioxidants
Subjects:
heme oxygenase 1
<i>Trypanosoma brucei</i>
inflammatory bowel disease
aromatic ketoacids
dendritic cells
immunomodulation
Online Access:https://www.mdpi.com/2076-3921/11/1/164
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