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Interplay between ubiquitin, SUMO and poly(ADP-ribose) in the cellular response to genotoxic stress

Cells employ a complex network of molecular pathways to cope with endogenous and exogenous genotoxic stress. This multilayered response ensures that genomic lesions are efficiently detected and faithfully repaired in order to safeguard genome integrity. The molecular choreography at sites of DNA dam...

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Principais autores: Stefania ePellegrino, Matthias eAltmeyer
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016-04-01
Serier:Frontiers in Genetics
Fag:
Ubiquitin
Cancer
DNA damage response
genome stability
PARP
SUMO
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00063/full
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