Interplay between ubiquitin, SUMO and poly(ADP-ribose) in the cellular response to genotoxic stress

Cells employ a complex network of molecular pathways to cope with endogenous and exogenous genotoxic stress. This multilayered response ensures that genomic lesions are efficiently detected and faithfully repaired in order to safeguard genome integrity. The molecular choreography at sites of DNA dam...

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Hauptverfasser:	Stefania ePellegrino, Matthias eAltmeyer
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2016-04-01
Schriftenreihe:	Frontiers in Genetics
Schlagworte:	Ubiquitin Cancer DNA damage response genome stability PARP SUMO
Online-Zugang:	http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00063/full
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