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Human Host Defense Peptide LL-37 Suppresses TNFα-Mediated Matrix Metalloproteinases MMP9 and MMP13 in Human Bronchial Epithelial Cells

Introduction: TNFα-inducible matrix metalloproteinases play a critical role in the process of airway remodeling in respiratory inflammatory disease including asthma. The cationic host defense peptide LL-37 is elevated in the lungs during airway inflammation. However, the impact of LL-37 on TNFα-driv...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Anthony Altieri, Courtney Lynn Marshall, Padmanie Ramotar, Dylan Lloyd, Mahadevappa Hemshekhar, Victor Spicer, Anne M. van der Does, Neeloffer Mookherjee
Format: Artigo
Sprache:Inglês
Veröffentlicht: Karger Publishers 2024-03-01
Schriftenreihe:Journal of Innate Immunity
Schlagworte:
cathelicidin
ll-37
tnfα
host defense peptides
inflammation
matrix metalloproteinases
airway remodeling
Online-Zugang:https://beta.karger.com/Article/FullText/537775
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