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Research progress on the α-synuclein-lysosome axis in Parkinson’s disease: molecular mechanisms of protein aggregation, autophagy dysfunction, and therapeutic targeting

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized pathologically by the loss of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies, which predominantly consist of misfolded α-synuclein (α-Syn) aggregates. Recent advan...

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書誌詳細
主要な著者: Jiaojiao Fu, Chuanxi Zhu, Zhenzhen Fan
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2026-07-01
シリーズ:Frontiers in Neuroscience
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オンライン・アクセス:https://www.frontiersin.org/articles/10.3389/fnins.2026.1885103/full
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