Research progress on the α-synuclein-lysosome axis in Parkinson’s disease: molecular mechanisms of protein aggregation, autophagy dysfunction, and therapeutic targeting
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized pathologically by the loss of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies, which predominantly consist of misfolded α-synuclein (α-Syn) aggregates. Recent advan...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2026-07-01
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| Serie: | Frontiers in Neuroscience |
| Soggetti: | |
| Accesso online: | https://www.frontiersin.org/articles/10.3389/fnins.2026.1885103/full |
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