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Research progress on the α-synuclein-lysosome axis in Parkinson’s disease: molecular mechanisms of protein aggregation, autophagy dysfunction, and therapeutic targeting

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized pathologically by the loss of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies, which predominantly consist of misfolded α-synuclein (α-Syn) aggregates. Recent advan...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Jiaojiao Fu, Chuanxi Zhu, Zhenzhen Fan
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2026-07-01
Rangatū:Frontiers in Neuroscience
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fnins.2026.1885103/full
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