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Enhanced cleaning strategies for UF/DF membranes in biopharmaceutical downstream processing

Abstract Membrane fouling during ultrafiltration/diafiltration (UF/DF) remains a major challenge for extending membrane lifetime in biologics manufacturing. Developing cleaning strategies that combine high efficiency with scalability is essential for robust downstream processing. In this study, diff...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Xinye Han, Zhenhao Bian, Xuyue Han, Huaguang Wang, Han Liu, Yajuan Zhou, Yiqing Cui, Xumei Liu
Format: Artigo
Sprache:Inglês
Veröffentlicht: SpringerOpen 2026-04-01
Schriftenreihe:Bioresources and Bioprocessing
Schlagworte:
Ultrafiltration/diafiltration (UF/DF)
Membrane fouling
Cleaning strategies
Permeate-closed cleaning
Backwashing
Biologics downstream processing
Online-Zugang:https://doi.org/10.1186/s40643-026-01045-0
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