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Enhanced cleaning strategies for UF/DF membranes in biopharmaceutical downstream processing

Abstract Membrane fouling during ultrafiltration/diafiltration (UF/DF) remains a major challenge for extending membrane lifetime in biologics manufacturing. Developing cleaning strategies that combine high efficiency with scalability is essential for robust downstream processing. In this study, diff...

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Principais autores: Xinye Han, Zhenhao Bian, Xuyue Han, Huaguang Wang, Han Liu, Yajuan Zhou, Yiqing Cui, Xumei Liu
Format: Artigo
Sprog:Inglês
Udgivet: SpringerOpen 2026-04-01
Serier:Bioresources and Bioprocessing
Fag:
Ultrafiltration/diafiltration (UF/DF)
Membrane fouling
Cleaning strategies
Permeate-closed cleaning
Backwashing
Biologics downstream processing
Online adgang:https://doi.org/10.1186/s40643-026-01045-0
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