The effect of combining HIV latency reversal with inhibition of phosphoinositide-3 kinases or B-cell lymphoma-2 on the HIV reservoir.

The persistence of latently infected CD4 + T-cells in people with HIV (PWH) on suppressive antiretroviral therapy (ART) is the major barrier to an HIV cure. We investigated the impact of two classes of pro-apoptotic drugs, phosphoinositide-3 kinases (PI3K) inhibitors or the B cell lymphoma 2 (Bcl-2)...

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Autors principals:	Youry Kim, Jenny L Anderson, Carolin Tumpach, Ajantha Solomon, Jesslyn Ong, Kiho Tanaka, Jennifer M Zerbato, Tania Tan, Charis E Teh, Daniel H D Gray, Philip Arandjelovic, James McMahon, Niamh Meagher, David Price, Marc Pellegrini, Michael Roche, Sharon R Lewin
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2026-01-01
Col·lecció:	PLoS Pathogens
Accés en línia:	https://doi.org/10.1371/journal.ppat.1013923
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