Methaneseleninic acid, a circadian-modulating agent, reactivates latent HIV-1 infection without cellular activation or proliferation

ABSTRACT Human immunodeficiency virus (HIV)-1 transcriptional activity is under circadian control in virally suppressed people with HIV (PWH), and circadian transcription factors can positively affect HIV transcription in vitro. We aimed to determine whether pharmacologic modulation of cell-autonomo...

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Detalhes bibliográficos

Principais autores:	Jared Stern, Rory A. Shepherd, Youry Kim, Carolin Tumpach, Kirsten E. Amos, Oscar H. Lloyd Williams, Swati Varshney, Hannah A. D. King, Ajantha Rhodes, Sharon R. Lewin, Michael Roche
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2026-03-01
coleção:	Journal of Virology
Assuntos:	selenium latency reversal HIV circadian T-cell proliferation
Acesso em linha:	https://journals.asm.org/doi/10.1128/jvi.01983-25
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