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Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine Kras(G12D)-induced skin carcinogenesis in vivo.

BACKGROUND: The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis. To study the role of Notch and oncogenic Kras signaling in a progenitor cell population, Pdx1-Cre mice were utilize...

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Principais autores: Pawel K Mazur, Barbara M Grüner, Hassan Nakhai, Bence Sipos, Ursula Zimber-Strobl, Lothar J Strobl, Freddy Radtke, Roland M Schmid, Jens T Siveke
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2010-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC2962652?pdf=render
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