Epigenome editing-mediated restoration of FBN1 expression by demethylation of CpG island shore in porcine fibroblasts

Fibrillin-1, an extracellular matrix protein encoded by the FBN1 gene, is crucial for maintaining connective tissue integrity. Mutations in FBN1 result in haploinsufficiency, leading to Marfan syndrome, in which the expression of functional FBN1 is correlated with disease onset and severity. Recent...

詳細記述

書誌詳細

主要な著者:	Rio Miyadai, Shiori Hinata, Yuya Amemiya, Satori Shigematsu, Kazuhiro Umeyama, Hiroshi Nagashima, Kenji Yamatoya, Jun Ohgane
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2025-06-01
シリーズ:	Biochemistry and Biophysics Reports
主題:	Epigenome editing CpG island shore FBN1 Haploinsufficiency DNA methylation dCas9-TET1
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2405580825000603
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!