Código QR (código de barras bidimensional)

Epigenome editing-mediated restoration of FBN1 expression by demethylation of CpG island shore in porcine fibroblasts

Fibrillin-1, an extracellular matrix protein encoded by the FBN1 gene, is crucial for maintaining connective tissue integrity. Mutations in FBN1 result in haploinsufficiency, leading to Marfan syndrome, in which the expression of functional FBN1 is correlated with disease onset and severity. Recent...

Fuld beskrivelse

Na minha lista:
Principais autores: Rio Miyadai, Shiori Hinata, Yuya Amemiya, Satori Shigematsu, Kazuhiro Umeyama, Hiroshi Nagashima, Kenji Yamatoya, Jun Ohgane
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-06-01
Serier:Biochemistry and Biophysics Reports
Fag:
Epigenome editing
CpG island shore
FBN1
Haploinsufficiency
DNA methylation
dCas9-TET1
Online adgang:http://www.sciencedirect.com/science/article/pii/S2405580825000603
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker