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Novel therapeutic potential of the PARP inhibitor talazoparib in synovial sarcoma and its combined effect with ATR inhibitor

Abstract Background Synovial sarcoma (SS) is a rare soft tissue sarcoma (STS) with limited treatment options, indicating the need for novel therapeutic strategies. In this study, we investigated the efficacy of talazoparib, a poly (ADP-ribose) polymerase enzyme (PARP) inhibitor, and DNA damage respo...

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Principais autores: Noritaka Honda, Hirokazu Taniguchi, Sawana Ono, Fumiko Hayashi, Erika Imamura, Hiroshi Gyotoku, Shinnosuke Takemoto, Takahiro Takazono, Hiroshi Ishimoto, Noriho Sakamoto, Yasushi Obase, Mitsuko Masutani, Tomoya Nishino, Hiroshi Mukae
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2026-01-01
coleção:Discover Oncology
Assuntos:
Synovial sarcoma
PARP
ATR
DNA damage
Acesso em linha:https://doi.org/10.1007/s12672-026-04422-5
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