Talazoparib and radiation enhance the senolytic efficacy of venetoclax in therapy-induced senescent triple-negative breast cancer cells

Abstract Triple-negative breast cancer (TNBC) presents ongoing clinical challenges, often leading to relapse in many patients. The relapse is partly explained by tumor cells transitioning into a senescent state following chemotherapy or radiation, resulting in a more aggressive phenotype, contributi...

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Detalles Bibliográficos

Principais autores:	Sultan Almudimeegh, Mashal M. Almutairi, Abrar Softah, Khalid Alhazzani, Lama Binobaid, Musaad Alshammari, Homood M. As Sobeai, Tareq Saleh, Moureq R. Alotaibi, Ali Alhoshani
Formato:	Artigo
Idioma:	Inglês
Publicado:	Springer 2025-08-01
Series:	Saudi Pharmaceutical Journal
Assuntos:	Venetoclax TNBC Senescence PARPi Radiotherapy (Min.5-Max. 8)
Acceso en liña:	https://doi.org/10.1007/s44446-025-00034-2
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