Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate

Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ transplant rejection and to treat autoimmune diseases. MMF usage, however, is limited by severe gastrointestinal toxicity that is observed in approximately 45% of MMF recipients. The active form of the...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Joshua B. Simpson, Josh J. Sekela, Amanda L. Graboski, Valentina B. Borlandelli, Marissa M. Bivins, Natalie K. Barker, Alicia A. Sorgen, Angie L. Mordant, Rebecca L. Johnson, Aadra P. Bhatt, Anthony A. Fodor, Laura E. Herring, Hermen Overkleeft, John R. Lee, Matthew. R. Redinbo
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Taylor & Francis Group 2022-12-01
Sarja:	Gut Microbes
Aiheet:	Multi-Omics Metagenomics Proteomics Metaproteomics Microbiome Glycoside Hyrolase
Linkit:	https://www.tandfonline.com/doi/10.1080/19490976.2022.2107289
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!