QR-Code

Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate

Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ transplant rejection and to treat autoimmune diseases. MMF usage, however, is limited by severe gastrointestinal toxicity that is observed in approximately 45% of MMF recipients. The active form of the...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Joshua B. Simpson, Josh J. Sekela, Amanda L. Graboski, Valentina B. Borlandelli, Marissa M. Bivins, Natalie K. Barker, Alicia A. Sorgen, Angie L. Mordant, Rebecca L. Johnson, Aadra P. Bhatt, Anthony A. Fodor, Laura E. Herring, Hermen Overkleeft, John R. Lee, Matthew. R. Redinbo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis Group 2022-12-01
Schriftenreihe:Gut Microbes
Schlagworte:
Multi-Omics
Metagenomics
Proteomics
Metaproteomics
Microbiome
Glycoside Hyrolase
Online-Zugang:https://www.tandfonline.com/doi/10.1080/19490976.2022.2107289
Tags: Tag hinzufügen
Keine Tags, Fügen Sie das erste Tag hinzu!

Ähnliche Einträge