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Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate

Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ transplant rejection and to treat autoimmune diseases. MMF usage, however, is limited by severe gastrointestinal toxicity that is observed in approximately 45% of MMF recipients. The active form of the...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Joshua B. Simpson, Josh J. Sekela, Amanda L. Graboski, Valentina B. Borlandelli, Marissa M. Bivins, Natalie K. Barker, Alicia A. Sorgen, Angie L. Mordant, Rebecca L. Johnson, Aadra P. Bhatt, Anthony A. Fodor, Laura E. Herring, Hermen Overkleeft, John R. Lee, Matthew. R. Redinbo
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Taylor & Francis Group 2022-12-01
Rangatū:Gut Microbes
Ngā marau:
Multi-Omics
Metagenomics
Proteomics
Metaproteomics
Microbiome
Glycoside Hyrolase
Urunga tuihono:https://www.tandfonline.com/doi/10.1080/19490976.2022.2107289
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