Generation and characterization of a HEK293 cell line optimized for recombinant adeno-associated virus production

HEK293 is a preferred cellular platform to produce viral vectors including adeno-associated viruses (AAV). However, HEK293 cells were shown to be genomically unstable and many HEK293 cell lines having distinct genotypes and phenotypes have been reported. Here we generated a stable clonal cell line s...

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主要な著者:	Mélissa Vona, Iris Bodenmann, Marc-Antoine Perrenoud, Rachel Buchs, Pelin Kolcak Yasli, Luca Nanni, Romain Daveau, Alexandre Félix, Jens Stolte, Ann-Kristin Hov, Bertrand Chollet, Thierry Schuepbach, Déborah Ley, Efrain Guzman, Igor Fisch, Nicolas Mermod
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2026-03-01
シリーズ:	Biotechnology Reports
主題:	Cell line development Viral vector production Adeno-associated viral vectors Human cell lines
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2215017X26000044
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