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Scalable production and purification of engineered ARRDC1-mediated microvesicles in a HEK293 suspension cell system

Abstract Engineering of human ARRDC1-mediated microvesicles (ARMMs) as non-viral vehicles for delivery of gene therapies bears the potential to enable novel therapeutic paradigms. We evaluated two scalable strategies to generate ARMMs loaded with protein cargo, by transient transfection or stable ce...

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Principais autores: Kristin Luther, Ali Navaei, Leah Gens, Carson Semple, Pearl Moharil, Ilaria Passalacqua, Komal Vyas, Qiyu Wang, Shu-Lin Liu, Lucy Sun, Senthil Ramaswamy, Davide Zocco, Joseph F. Nabhan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-03-01
Serier:Scientific Reports
Fag:
Extracellular vesicles
ARRDC1-mediated microvesicles
ARMMs
5B8
Transient transfection
Stable producer cell line
Online adgang:https://doi.org/10.1038/s41598-025-87674-5
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