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Hyperactivation of ATF4/TGF-β1 signaling contributes to the progressive cardiac fibrosis in Arrhythmogenic cardiomyopathy caused by DSG2 Variant

Abstract Background Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy characterized with progressive cardiac fibrosis and heart failure. However, the exact mechanism driving the progression of cardiac fibrosis and heart failure in ACM remains elusive. This study aims to investigate...

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Principais autores: Baowei Zhang, Yizhang Wu, Chunjiang Zhou, Jiaxi Xie, Youming Zhang, Xingbo Yang, Jing Xiao, Dao Wu Wang, Congjia Shan, Xiujuan Zhou, Yaozu Xiang, Bing Yang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-09-01
coleção:BMC Medicine
Assuntos:
Arrhythmogenic cardiomyopathy
Desmoglein 2
Cardiac fibrosis
Transforming growth factor β1
Activating transcription factor 4
Acesso em linha:https://doi.org/10.1186/s12916-024-03593-8
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