Apremilast improves cardiomyocyte cohesion and arrhythmia in different models for arrhythmogenic cardiomyopathy

Abstract Background Arrhythmogenic cardiomyopathy (ACM) is a genetically inherited desmosome heart disease leading to life-threatening arrhythmias and sudden cardiac death. Currently, ACM treatment paradigms are merely symptom targeting. Recently, apremilast was shown to stabilize keratinocyte adhes...

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Principais autores:	Konstanze Stangner, Orsela Dervishi, Janina Kuhnert, Carl Wendt, Soumyata Pathak, Maria Shoykhet, Silvana Olivares-Florez, Sina Moztarzadeh, Jens Opsteen, Ni Luh Cathrin Suniasih Wohlfarth, Ruth Biller, Elisabeth Graf, Dominik S. Westphal, Tatjana Williams, Brenda Gerull, Tomo Šarić, Sunil Yeruva, Jens Waschke
格式:	Artigo
语言:	Inglês
出版:	BMC 2025-11-01
丛编:	Stem Cell Research & Therapy
主题:	Apremilast Arrhythmogenic cardiomyopathy Arrhythmia Desmoplakin and desmoglein 2
在线阅读:	https://doi.org/10.1186/s13287-025-04755-y
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