Reactivation of PPARα alleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acid β-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM), a fatal heart disease characterized by fibroadipocytic replacement of cardiac myocytes, accounts for 20% of sudden cardiac death and lacks effective treatment. It is often caused by mutations in desmosome proteins, with Desmoglein-2 (DSG2) mutations as a common e...

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Detalhes bibliográficos

Principais autores:	Yubi Lin, Ruonan Liu, Yanling Huang, Zhe Yang, Jianzhong Xian, Jingmin Huang, Zirui Qiu, Xiufang Lin, Mengzhen Zhang, Hui Chen, Huadong Wang, Jiana Huang, Geyang Xu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-01-01
coleção:	Acta Pharmaceutica Sinica B
Assuntos:	Arrhythmogenic cardiomyopathy Desmosome Desmoglein2 Heart failure Lipid accumulation mTOR
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211383522002404
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