The Distinctive Activation of Toll-Like Receptor 4 in Human Samples with Sepsis

Clinical success of Toll-Like receptor-4 (TLR-4) antagonists in sepsis therapy has thus far been lacking. As inhibition of a receptor can only be useful if the receptor is active, stratification of patients with active TLR-4 would be desirable. Our aim was to establish an assay to quantify phosphory...

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Hlavní autoři:	Patrick Thon, Katharina Rump, Annika Knorr, Birte Dyck, Dominik Ziehe, Matthias Unterberg, Hartmuth Nowak, Lars Bergmann, Alexander Wolf, Maha Bazzi, Jennifer Orlowski, Marcus Peters, Alexander Zarbock, Thorsten Brenner, Michael Adamzik, Tim Rahmel, Björn Koos
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-09-01
Edice:	Cells
Témata:	sepsis Toll-Like Receptor 4 proximity ligation assay
On-line přístup:	https://www.mdpi.com/2073-4409/11/19/3020
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