DUAL INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE (IDO) AND TRYPTOPHAN-2,3-DIOXYGENASE (TDO) AS ANTI-TUMOR IMMUNE MODULATORS
Indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO) are enzymes that catalyze the rate-limiting step of the kynurenine pathway. Recent literature reports IDO and TDO upregulation in tumor cells leading to L-tryptophan depletion and accumulation of tryptophan metabolites. This proc...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Al-Azhar University, Faculty of Pharmacy
2024-03-01
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| Serija: | Al-Azhar Journal of Pharmaceutical Sciences |
| Teme: | |
| Online pristup: | https://ajps.journals.ekb.eg/article_360357_9f3e15efbb529e3a0703e5f6ad7febeb.pdf |
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