Indoleamine 2,3-dioxygenase 1 as a metabolic switch in sepsis-induced immunosuppression: transcriptomic validation and therapeutic inhibition by novel quinoline derivativesNCBI-GEO

Sepsis is a life-threatening condition driven by a dysregulated immune response, remains a leading cause of ICU mortality due to its complex, heterogeneous pathophysiology. This study employed a systems biology approach to analyze human transcriptomic data (GSE128303), identifying phase-specific mol...

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Detalles Bibliográficos

Principais autores:	Deepthi Sreepathi, Hulikal Shivashankar Santosh Kumar, Gollapalli Pavan, Nayak Devappa Satyanarayana
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2026-01-01
Series:	In Silico Research in Biomedicine
Assuntos:	Sepsis Immunosuppression Indoleamine 2,3-dioxygenase 1 Kynurenine pathway Quinoline derivatives
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S3050787126001290
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