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DUAL INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE (IDO) AND TRYPTOPHAN-2,3-DIOXYGENASE (TDO) AS ANTI-TUMOR IMMUNE MODULATORS

Indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO) are enzymes that catalyze the rate-limiting step of the kynurenine pathway. Recent literature reports IDO and TDO upregulation in tumor cells leading to L-tryptophan depletion and accumulation of tryptophan metabolites. This proc...

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Autori principali: Mostafa Abouzeid, Mohamed Ayman El-Zahabi, Ibrahim Eissa, Mohamed Taghour
Natura: Artigo
Lingua:Inglês
Pubblicazione: Al-Azhar University, Faculty of Pharmacy 2024-03-01
Serie:Al-Azhar Journal of Pharmaceutical Sciences
Soggetti:
Indoleamine-2
tryptophan-2
3-dioxygenase
dual inhibitors
anti-tumor immune modulators
Accesso online:https://ajps.journals.ekb.eg/article_360357_9f3e15efbb529e3a0703e5f6ad7febeb.pdf
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