Research progress of proteolysis-targeting chimeras in viral hepatitis drug discovery

Proteolysis Targeting Chimera (PROTAC) is an innovative drug discovery strategy that utilizes bifunctional small molecules to bring a target protein (POI) into proximity with an E3 ubiquitin ligase, thereby inducing ubiquitination of the pathogenic protein and its subsequent degradation by the prote...

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Auteurs principaux:	Xiaofei Hao, Yanli Wang, Gang Huang, Chaoyang Lin, Peng Zhao, Wubin Zhi, Xiankai Li, Peng Qi, Peng Liu
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2026-06-01
Collection:	Frontiers in Chemistry
Sujets:	antiviral drugs fluorine hepatitis virus PROTAC resistance
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fchem.2026.1810498/full
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